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One or more keywords matched the following items that are connected to Cook, Paul
Item TypeName
Concept Cysteine Synthase
Concept Tryptophan Synthase
Concept Dihydropteroate Synthase
Academic Article Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase.
Academic Article Purification and properties of beta-alanine synthase from calf liver.
Academic Article A three-dimensional homology model of the O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
Academic Article Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.
Academic Article Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Academic Article Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.
Academic Article Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase.
Academic Article Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature.
Academic Article The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase.
Academic Article pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
Academic Article Formation of the alpha-aminoacrylate immediate limits the overall reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase.
Academic Article Alpha,beta-elimination reaction of O-acetylserine sulfhydrylase. Is the pyridine ring required?
Academic Article Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Academic Article (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
Academic Article Isozyme-specific ligands for O-acetylserine sulfhydrylase, a novel antibiotic target.
Academic Article Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate.
Academic Article Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
Academic Article O-acetylserine sulfhydrylase.
Academic Article Stabilization and characterization of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae.
Academic Article Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. II. Theory.
Academic Article Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. I. Kinetic studies.
Academic Article A rapid purification procedure and computer-assisted sulfide ion selective electrode assay for O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium.
Academic Article Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae.
Academic Article A two-step process controls the formation of the bienzyme cysteine synthase complex.
Academic Article Kinetic and chemical mechanisms of homocitrate synthase from Thermus thermophilus.
Academic Article Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase.
Academic Article Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
Academic Article Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry.
Academic Article Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound.
Academic Article Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase.
Academic Article Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Academic Article Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy.
Academic Article salmonella typhimurium/enzymol.
Academic Article Cysteine synthetase from Salmonella typhimurium LT-2. Aggregation, kinetic behavior, and effect of modifiers.
Academic Article Overall mechanism and rate equation for O-acetylserine sulfhydrylase.
Academic Article Resolution of pyridoxal 5'-phosphate from O-acetylserine sulfhydrylase from Salmonella typhimurium and reconstitution of apoenzyme with cofactor and cofactor analogues as a probe of the cofactor binding site.
Academic Article Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.
Academic Article Crystallization and preliminary X-ray data for the A-isozyme of O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants.
Grant Lysine Biosynthesis in Yeast
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  • Glycogen Synthase